The player with the Avatar of Fire begins the game.

If no player controls the Avatar, the player with the Earth Avatar begins the game.

If also no player controls the Avatar of Earth, the player with the Avatar of Light begins the game.

If also no player controls the Avatar of Light, the player with the Avatar of Life begins the game.

If also no player controls the Avatar of Life, the player with the Avatar of Water begins the game.

The player with the Avatar of the Dark consequently never begins.

Once a player manages to liberate their Heaven (their hand) from all cards, they immediately win the game.

Since in standard conditions every player needs to take a new card and may take only one die every turn - and can consequently play only one card per turn, players need to utilise effects of cards in order to change standard conditions in favour of themselves.

E.g. effects of cards can allow to discard or not to take cards or to take multiple dies.

In standard conditions, a player takes a die in the beginning of their turn and can use it to perform an action. If the player would have more dies at disposal (thanks to certain effects), they can perform an action with every die. Depending on the action, dies can be rolled or simply discarded to perform the action.

In the standard game Iuno Avatar players can use their dies to perform the following actions:​

• They discard the die to summon a figure card by paying its cost and moving it from Heaven to Earth

• They can discard the die to cast a spell card by paying its cost and moving it from Heaven to Earth

• They can roll the die to activate/level up a figure card on Earth by moving a(nother) gem on top of it: the action is successful, when the rolled number exceeds the number of gems on top of the figure
  

In the Iuno Artifact extension, player additionally can perform the following actions:

• They can use a die equip one of their figure cards on Earth with an artifact card by paying its cost, taking it from Heaven (or from Earth) and attaching it to the figure card

• They can use a die to let an active figures play their one-time effect

• They can use a die to let an active figure attack the opponent or an opponent's figure

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Discarded or rolled dies are put back in the middle of the table. An action needs to be finished, before the player can play another one (in case they would have more than one die available).

If there would be no dies or gems left in the middle of the table, the player can take a die or gem from the players with the most dies/gems.

If there are no cards left in the card stack, Hell gets shuffled and replaces the stack face down.